Webseite University Leipzig, Medical Faculty, Institute of Drug Dicovery
In order to characterize the different capsid glycan interactions, you will work mainly with the state of the art software for molecular modeling and design, called Rosetta. In your work you will use Rosetta through command line applications (Linux, Bash) and you will write scripts to analyze structural models (e.g. in Python/R). At the start of the project you will use homology modeling and ligand docking to understand the different capsid-glycan interactions, and then use this knowledge to create new AAV variants through protein design. You will be mentored by me (PhD Student) and Dr. Clara Schoeder (junior group leader) at our institute, where you will have your own work space in our office with a highperformance workstation.
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